What steroid regimens are used for checkpoint inhibitor irAEs?

Grade 2 (moderate): hold immunotherapy, prednisone 0.5–1 mg/kg/day, taper over 4–6 weeks. Grade 3 (severe): hospitalize, methylprednisolone 1–2 mg/kg/day IV, hold immunotherapy permanently for most Grade 3+. Infliximab 5 mg/kg for steroid-refractory colitis. Mycophenolate for steroid-refractory hepatitis.

Can immunotherapy be resumed after irAE?

Grade 1–2 events that resolve to ≤1 with steroids tapered: may resume with close monitoring. Grade 3 events: most guidelines recommend permanent discontinuation; some allow resumption after resolution of select toxicities (rash, endocrinopathies) at physician discretion. Grade 4 life-threatening: permanent discontinuation universally recommended.

Pembrolizumab Immune-Related Adverse Event Severity Score

Grade pembrolizumab and other PD-1/PD-L1 inhibitor immune-related adverse events by organ system using CTCAE v5, with NCCN/SITC-aligned management (hold, high-dose steroids, infliximab, hospitalization).

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Pembrolizumab Immune-Related Adverse Event Severity Score

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Frequently Asked Questions

What steroid regimens are used for checkpoint inhibitor irAEs?

Can immunotherapy be resumed after irAE?