How is PDAI calculated in pemphigus vulgaris?

PDAI has three components: skin activity (0–120), scalp activity (0–10), and mucous membrane activity (0–34). Total = 164. Scores 0: complete remission; 1–8: mild; 9–24: moderate; ≥25: severe. PDAI drives treatment decisions and is the primary endpoint in rituximab trials.

What is the role of rituximab in pemphigus?

Rituximab is now first-line for moderate-severe pemphigus vulgaris (PDAI ≥9). The Ritux 3 protocol (1000 mg × 2 doses 2 weeks apart + tapered prednisone) achieves complete remission at 24 months in ~90% of patients, far superior to prednisone alone.

Pemphigus Disease Area Index (PDAI)

Calculate PDAI for pemphigus vulgaris/foliaceus by scoring active lesions (0–120) and damage/post-inflammatory changes across skin and mucosal surfaces to guide immunosuppressive treatment.

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Pemphigus Disease Area Index (PDAI)

Frequently Asked Questions

How is PDAI calculated in pemphigus vulgaris?

What is the role of rituximab in pemphigus?