What does PDAI assess in pemphigus?

PDAI separates activity from damage. Activity score: skin, scalp, and mucous membrane blistering and erosions. Damage score: post-inflammatory hyperpigmentation and scarring. Treatment decisions use activity score alone.

When is rituximab indicated in pemphigus?

Rituximab (anti-CD20) is now first-line (preferred over high-dose steroids) for new-onset moderate-to-severe PV (PDAI >15) per EADV 2020 guidelines. RITUX 3 trial showed superiority over prednisone for complete remission.

What is complete remission in pemphigus?

Complete remission off therapy (CROT): absence of new/established lesions for >=2 months after all systemic therapies stopped. Complete remission on minimal therapy (CRMT): absence of new lesions while on prednisone <=10mg/day.

Pemphigus Vulgaris PDAI Scoring

Score pemphigus vulgaris activity using PDAI (Pemphigus Disease Area Index): skin activity (0-250), scalp activity (0-10), mucous membrane activity (0-40). Severe >45.

Use the full interactive calculator below, or

Pemphigus Vulgaris PDAI Scoring

Frequently Asked Questions

What does PDAI assess in pemphigus?

When is rituximab indicated in pemphigus?

What is complete remission in pemphigus?