What is the prophylactic platelet transfusion threshold?

Prophylactic transfusion at <10,000/µL for stable patients without risk factors (PLADO trial). Increase to <20,000/µL with fever, infection, plasma proteins abnormalities, or minor bleeding. <50,000/µL for most invasive procedures.

How much does one apheresis platelet unit raise the platelet count?

One apheresis unit (equivalent to 6 pooled random donor units) typically raises platelet count by 30,000–60,000/µL. Expected 1-hour CCI (corrected count increment) >7,500 indicates adequate response.

What is platelet refractoriness?

Platelet refractoriness is defined as a 1-hour post-transfusion CCI <7,500 on two consecutive occasions with ABO-compatible platelets. Causes: alloimmunization (HLA antibodies), fever, sepsis, DIC, splenomegaly. Management: HLA-matched platelets for immune refractoriness.

Platelet Transfusion Threshold Guidelines

Provides evidence-based platelet transfusion thresholds: prophylactic <10,000/µL (stable), <20,000/µL (with risk factors), <50,000/µL (invasive procedures/surgery), <100,000/µL (CNS surgery, ocular surgery, epidural placement). Includes dose and expected increment calculations.

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Frequently Asked Questions

What is the prophylactic platelet transfusion threshold?

How much does one apheresis platelet unit raise the platelet count?

What is platelet refractoriness?