What ARR cutoff is used for PA screening?

ARR >30 (ng/dL)/(ng/mL/h) or >750 (pmol/L)/(mU/L) is the most widely used screening threshold. ARR >30 plus aldosterone >15 ng/dL has high sensitivity for PA. Confirmatory testing is required.

What AVS lateralization index confirms unilateral PA?

AVS lateralization index (higher:lower adrenal aldosterone:cortisol ratio) >=4 confirms unilateral hypersecretion after successful cannulation (selectivity index >=2). Index <3 suggests bilateral disease.

When can CT scan replace AVS in PA?

CT can replace AVS in patients 1cm on CT - very low risk of bilateral disease in this scenario.

Primary Hyperaldosteronism Lateralization ARR

Use aldosterone-to-renin ratio (ARR) for primary hyperaldosteronism (PA) screening and adrenal vein sampling (AVS) lateralization index >=4 to guide adrenalectomy vs medical management.

Use the full interactive calculator below, or

Primary Hyperaldosteronism Lateralization ARR

Frequently Asked Questions

What ARR cutoff is used for PA screening?

What AVS lateralization index confirms unilateral PA?

When can CT scan replace AVS in PA?