Calculates propofol infusion for ICU sedation targeting RASS −2 to 0. Typical range: 0.3–4 mg/kg/h (5–67 mcg/kg/min). Higher-dose threshold for PRIS: monitor when >5 mg/kg/h or duration >48 hours. Implement daily spontaneous awakening trials. Monitor: serum triglycerides, lactate (PRIS), urine color, and creatine kinase.
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