What propofol doses are used for ICU sedation vs procedural sedation?

ICU sedation (target RASS -1 to -2): 5 to 50 mcg/kg/min (0.3 to 3 mg/kg/h). Procedural sedation: 100 to 200 mcg/kg/min induction then 25 to 100 mcg/kg/min maintenance. General anesthesia induction: 1 to 2.5 mg/kg IV bolus. Keep ICU doses <=4 mg/kg/h (67 mcg/kg/min) when possible to reduce PRIS risk.

What are the signs and risk factors for propofol infusion syndrome?

PRIS: metabolic acidosis, rhabdomyolysis, lipemia, cardiac failure (new RBBB/LBBB), hyperkalemia, hepatomegaly. Risk: dose >4 mg/kg/h for >48h, concurrent catecholamines or steroids, low carbohydrate intake, pediatric patients. PRIS is rare but mortality >30%. If suspected: stop propofol immediately, switch to alternative sedation.

Propofol Infusion Rate to Sedation Level Calculator

Calculate propofol infusion rate (mcg/kg/min) required to achieve target RASS or BIS, with safety thresholds for propofol infusion syndrome monitoring (>4 mg/kg/h for >48h increases PRIS risk).

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the scenario you are assessing. Calculate propofol infusion rate (mcg/kg/min) required to achieve target RASS or BIS, with safety thresholds for propofol infusion syndrome monitoring (>4 mg/kg/h for >48h increases PRIS risk). Use the propofol sedation rate result to inform your calculation.

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