What defines R-ISS Stage III?

R-ISS Stage III requires ISS Stage III (beta-2 microglobulin 5.5+ and albumin below 3.5) plus at least one of: high-risk FISH abnormality (del17p, t(4;14), t(14;16)) or elevated LDH above upper limit of normal. 5-year OS approximately 40%.

What is the 5-year OS difference across R-ISS stages?

R-ISS Stage I: 5-year OS approximately 82%. Stage II: 62%. Stage III: 40%. This compares favorably to the original ISS which showed less discrimination in the novel agent era, confirming cytogenetics add independent prognostic value.

R-ISS Myeloma Revised Staging

Apply Revised ISS (R-ISS) for multiple myeloma staging combining ISS, FISH cytogenetics (del17p, t(4;14), t(14;16)), and LDH to classify Stage I, II, or III with updated survival data.

Use the full interactive calculator below, or

Related Calculators

ISS Myeloma Staging

Medical

Free Light Chain Ratio

Medical Long-tail

R-ISS Myeloma Revised Staging

Related Calculators

Frequently Asked Questions

What defines R-ISS Stage III?

What is the 5-year OS difference across R-ISS stages?