What are Brigham T2b/T3 risk factors for SCC?

BWH risk factors: diameter >=2cm, poorly differentiated histology, perineural invasion >=0.1mm, or tumor invasion beyond subcutaneous fat. T2b (2-3 factors): 35% regional metastasis. T3 (>3 factors or bone invasion): 50%+ metastasis.

How does Brigham staging compare to AJCC 8th for SCC?

BWH staging is widely used and validated. AJCC 8th edition (head/neck SCC) adds parotid and nodal factors. Both systems identify T3-equivalent high-risk tumors requiring sentinel LN biopsy and/or adjuvant therapy consideration.

When is sentinel lymph node biopsy indicated for SCC?

SLNB is considered for BWH T2b-T3 or AJCC T3 SCC, particularly in immunosuppressed patients, tumors on head/neck/lip, recurrent lesions, and PNI tumors. SLNB positive rate is 8-14% for T2b tumors.

SCC Metastasis Prediction Brigham Staging

Predict cutaneous SCC metastasis risk using Brigham and Women's Hospital staging: T1 (0 risk factors), T2a (1 risk factor), T2b (2-3 risk factors), T3 (>3 risk factors or bone invasion).

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SCC Metastasis Prediction Brigham Staging

Frequently Asked Questions

What are Brigham T2b/T3 risk factors for SCC?

How does Brigham staging compare to AJCC 8th for SCC?

When is sentinel lymph node biopsy indicated for SCC?