Standard DOTS regimen for drug-sensitive pulmonary TB: Intensive phase — isoniazid (H) + rifampicin (R) + pyrazinamide (Z) + ethambutol (E) × 2 months. Continuation phase — isoniazid + rifampicin × 4 months. Total: 6 months. MDR-TB requires second-line agents for ≥20 months.
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