IV Valproate Loading & Maintenance Dose Calculator

Calculates IV valproate sodium (valproic acid) dosing for status epilepticus and seizure management. Loading dose: 15–45 mg/kg IV at 3–6 mg/kg/min (max rate 200 mg/min). Maintenance: 10–15 mg/kg/day divided q6–8h. Monitor for thrombocytopenia, hepatotoxicity, and hyperammonemia. Contraindicated in urea cycle disorders and mitochondrial disease.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How to Use

Enter the values for the scenario you are assessing. Calculates IV valproate sodium (valproic acid) dosing for status epilepticus and seizure management. Loading dose: 15–45 mg/kg IV at 3–6 mg/kg/min (max rate 200 mg/min). Maintenance: 10–15 mg/kg/day divided q6–8h. Monitor for thrombocytopenia, hepatotoxicity, and hyperammonemia. Contraindicated in urea cycle disorders and mitochondrial disease. Use the valproate iv result to inform your calculation.

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