How does PMA affect vancomycin dosing interval?

PMA under 29 weeks: 18 mg/kg q18h. PMA 30–35 weeks: 15 mg/kg q12h. PMA 36–44 weeks: 15 mg/kg q8h. PMA 45 weeks or greater: 15 mg/kg q6h. Renal immaturity at lower PMA requires longer intervals to avoid accumulation.

Should troughs or AUC be used to monitor neonatal vancomycin?

AUC/MIC-guided dosing (target AUC 400–600 mg·h/L) is preferred per recent ASHP/IDSA guidelines. Trough-only monitoring can mislead when distribution volume varies with gestational age. Bayesian dosing software is increasingly used in NICUs.

Vancomycin Neonatal Dose by PMA

Calculate vancomycin dosing interval and dose by postmenstrual age (PMA) and weight for neonatal sepsis, with AUC/MIC target-based dosing and trough monitoring guidance.

Use the full interactive calculator below, or

Related Calculators

Schwartz Pediatric GFR

Medical Long-tail

Pediatric Amoxicillin

Medical Long-tail

Vancomycin Neonatal Dose by PMA

Related Calculators

Frequently Asked Questions

How does PMA affect vancomycin dosing interval?

Should troughs or AUC be used to monitor neonatal vancomycin?