How do I choose between buprenorphine, methadone, and naltrexone?

Buprenorphine: first-line outpatient; methadone: severe dependence, poor buprenorphine response; naltrexone: motivated, opioid-free individuals, no risk of precipitated withdrawal.

What evidence supports MAT for opioid use disorder?

Buprenorphine reduces overdose mortality by 50%; methadone by 33%; naltrexone reduces relapse; all three are superior to abstinence-only approaches.

Medication-Assisted Treatment MAT Initiation

Guide medication-assisted treatment initiation decisions for opioid use disorder including buprenorphine, methadone, and naltrexone selection criteria.

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Medication-Assisted Treatment MAT Initiation

Frequently Asked Questions

How do I choose between buprenorphine, methadone, and naltrexone?

What evidence supports MAT for opioid use disorder?