What Breslow thickness determines T-stage in melanoma?

pT1a: 1.0-2.0 mm, no ulceration; pT2b: >1.0-2.0 mm, ulcerated; pT3a: >2.0-4.0 mm; pT3b: ulcerated; pT4a: >4 mm; pT4b: >4 mm ulcerated.

When is sentinel lymph node biopsy recommended?

SLNB recommended for melanoma ≥1.0 mm Breslow thickness; SLNB for 0.8-1.0 mm or <0.8 mm with ulceration (T1b); SLNB positive: consider completion lymph node dissection vs surveillance; MSLT-II trial supports surveillance over CLND.

What adjuvant therapy is indicated for stage III melanoma?

Stage III: anti-PD-1 (nivolumab, pembrolizumab) for 1 year reduces recurrence by 35-40%; BRAF V600E/K mutant: dabrafenib+trametinib targeted therapy reduces recurrence by 50%; stage II high-risk: pembrolizumab approved for IIB/IIC.

What BRAF mutation is the most important in melanoma?

BRAF V600E mutation (~50% cutaneous melanomas) confers sensitivity to BRAF inhibitors (vemurafenib, dabrafenib) combined with MEK inhibitors (trametinib, cobimetinib); response rate >70% but median PFS ~12 months without resistance.

What is the 5-year survival by melanoma stage?

Stage I: >98%; Stage II: 60-92% depending on substage; Stage III: 40-85% depending on substage/nodal burden; Stage IV (distant metastases): historically <15%, now 30-50% with modern immunotherapy+targeted therapy combinations.

Melanoma Breslow Thickness Staging and Sentinel Node Criteria

Calculates melanoma AJCC 8th edition T-stage from Breslow thickness and ulceration, estimates sentinel lymph node biopsy yield, and 5/10-year survival by stage with adjuvant immunotherapy eligibility.

Use the full interactive calculator below, or

Related Calculators

PASI Score

Medical Calculators

SCORAD Score

Medical Calculators

Fitzpatrick Phototype

Medical Calculators

Melanoma Breslow Thickness Staging and Sentinel Node Criteria

Related Calculators

Frequently Asked Questions

What Breslow thickness determines T-stage in melanoma?

When is sentinel lymph node biopsy recommended?

What adjuvant therapy is indicated for stage III melanoma?

What BRAF mutation is the most important in melanoma?

What is the 5-year survival by melanoma stage?