What Breslow thickness determines T-stage in melanoma?

pT1a: 1.0-2.0 mm, no ulceration; pT2b: >1.0-2.0 mm, ulcerated; pT3a: >2.0-4.0 mm; pT3b: ulcerated; pT4a: >4 mm; pT4b: >4 mm ulcerated.

When is sentinel lymph node biopsy recommended?

SLNB recommended for melanoma ≥1.0 mm Breslow thickness; SLNB for 0.8-1.0 mm or <0.8 mm with ulceration (T1b); SLNB positive: consider completion lymph node dissection vs surveillance; MSLT-II trial supports surveillance over CLND.

What adjuvant therapy is indicated for stage III melanoma?

Stage III: anti-PD-1 (nivolumab, pembrolizumab) for 1 year reduces recurrence by 35-40%; BRAF V600E/K mutant: dabrafenib+trametinib targeted therapy reduces recurrence by 50%; stage II high-risk: pembrolizumab approved for IIB/IIC.

What BRAF mutation is the most important in melanoma?

BRAF V600E mutation (~50% cutaneous melanomas) confers sensitivity to BRAF inhibitors (vemurafenib, dabrafenib) combined with MEK inhibitors (trametinib, cobimetinib); response rate >70% but median PFS ~12 months without resistance.

What is the 5-year survival by melanoma stage?

Stage I: >98%; Stage II: 60-92% depending on substage; Stage III: 40-85% depending on substage/nodal burden; Stage IV (distant metastases): historically <15%, now 30-50% with modern immunotherapy+targeted therapy combinations.

Melanoma Breslow Thickness Staging and Sentinel Node Criteria

Calculates melanoma AJCC 8th edition T-stage from Breslow thickness and ulceration, estimates sentinel lymph node biopsy yield, and 5/10-year survival by stage with adjuvant immunotherapy eligibility.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Calculates melanoma AJCC 8th edition T-stage from Breslow thickness and ulceration, estimates sentinel lymph node biopsy yield, and 5/10-year survival by stage with adjuvant immunotherapy eligibility

Each component has a specific meaning:

Breslow thickness — The breslow thickness recorded for the scenario being assessed.
Ulceration — The ulceration recorded for the scenario being assessed.
Estimates sentinel lymph node biopsy yield — The estimates sentinel lymph node biopsy yield recorded for the scenario being assessed.
5/10-year survival by stage — The 5/10-year survival by stage recorded for the scenario being assessed.

Note: Interpret the melanoma breslow stage result against the thresholds and context described above.

How to Use

Enter the Breslow thickness, ulceration, estimates sentinel lymph node biopsy yield, 5/10-year survival by stage for the scenario you are assessing. Calculates melanoma AJCC 8th edition T-stage from Breslow thickness and ulceration, estimates sentinel lymph node biopsy yield, and 5/10-year survival by stage with adjuvant immunotherapy eligibility. Use the melanoma breslow stage result to inform your calculation.

Related Calculators

PASI Score

Medical Calculators

SCORAD

Medical

Fitzpatrick Phototype