What are the T-stage cutoffs for Breslow thickness in melanoma?

AJCC 8th edition: T1a ≤0.8 mm no ulceration; T1b ≤0.8 mm with ulceration OR 0.8-1.0 mm; T2a 1.01-2.0 mm no ulceration; T2b 1.01-2.0 mm with ulceration; T3a 2.01-4.0 mm no ulceration; T3b with ulceration; T4a >4.0 mm; T4b >4.0 mm with ulceration.

When is sentinel lymph node biopsy recommended for melanoma?

SLNB recommended for T1b melanoma (0.8-1.0 mm or mitosis ≥1) where SLN status affects staging; strongly recommended T2a and beyond; factors indicating SLNB even for T1a: ulceration, regression, young age, high mitotic rate.

What excision margins are recommended by T-stage?

T1 (≤1.0 mm): 1 cm margin; T2 (1.01-2.0 mm): 1-2 cm margin; T3 (2.01-4.0 mm): 2 cm margin; T4 (>4.0 mm): 2 cm margin; margins based on Breslow thickness, not clinical width of lesion; histological confirmation essential.

Which melanoma subtypes have special features affecting prognosis?

Acral lentiginous melanoma (palms/soles, subungual): BRAF mutation less common, poorer prognosis; desmoplastic melanoma: low sentinel node positivity, high local recurrence risk; uveal melanoma: GNA11/GNAQ mutations; mucosal: aggressive, poor response to immunotherapy.

What adjuvant therapy is indicated for resected stage III melanoma?

Pembrolizumab and nivolumab (anti-PD-1) or dabrafenib+trametinib (if BRAF V600E/K positive) are approved adjuvant therapies for stage III resected melanoma; reduce recurrence risk 35-40%; duration 12 months.

Melanoma Breslow Thickness Staging and Sentinel Lymph Node Biopsy Criteria

Calculates melanoma T-stage by Breslow thickness and ulceration per AJCC 8th edition, sentinel lymph node biopsy eligibility criteria, and excision margin recommendations.

Weight

Height

Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the patient or scenario you are assessing. Calculates melanoma T-stage by Breslow thickness and ulceration per AJCC 8th edition, sentinel lymph node biopsy eligibility criteria, and excision margin recommendations. Use the melanoma breslow stage result to inform your clinical assessment.

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