When is genetic testing for MEN1 indicated?

MEN1 genetic testing is indicated when two or more MEN1-associated tumors are present, when primary hyperparathyroidism presents before age 40, or when there is a first-degree relative with confirmed MEN1.

What is the most common first manifestation of MEN1?

Primary hyperparathyroidism is the most common first manifestation (>90% of MEN1 patients), typically presenting in the third decade, often multifocal or multiglandular, unlike sporadic PHPT.

MEN1 Probability Score — Multiple Endocrine Neoplasia Type 1

Calculate clinical probability of MEN1 syndrome based on the presence and combination of primary hyperparathyroidism, enteropancreatic tumors, and anterior pituitary adenomas to guide genetic testing.

Use the full interactive calculator below, or

MEN1 Probability Score — Multiple Endocrine Neoplasia Type 1

Frequently Asked Questions

When is genetic testing for MEN1 indicated?

What is the most common first manifestation of MEN1?