High-Dose Methotrexate Toxicity and Leucovorin Rescue Calculator

Calculates leucovorin rescue dosing for high-dose methotrexate based on serum MTX levels at 24h/48h/72h, renal function decline, and delayed clearance criteria per standardized MTX elimination protocols.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculates leucovorin rescue dosing for high-dose methotrexate based on serum MTX levels at 24h/48h/72h, renal function decline, and delayed clearance criteria per standardized MTX elimination protocols

Each component has a specific meaning:

  • Serum MTX levels at 24h/48h/72h — The serum mtx levels at 24h/48h/72h recorded for the scenario being assessed.
  • Renal function decline — The renal function decline recorded for the scenario being assessed.
  • Delayed clearance criteria per standardized MTX elimination protocols — The delayed clearance criteria per standardized mtx elimination protocols recorded for the scenario being assessed.

Note: Interpret the mtx leucovorin rescue result against the thresholds and context described above.

How to Use

Enter the serum MTX levels at 24h/48h/72h, renal function decline, delayed clearance criteria per standardized MTX elimination protocols for the scenario you are assessing. Calculates leucovorin rescue dosing for high-dose methotrexate based on serum MTX levels at 24h/48h/72h, renal function decline, and delayed clearance criteria per standardized MTX elimination protocols. Use the mtx leucovorin rescue result to inform your calculation.

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Frequently Asked Questions