What MMF dose is used for renal transplant vs lupus nephritis?

Renal transplant: MMF 2-3 g/day in 2 divided doses (or EC-MPS 1440 mg/day); lupus nephritis: MMF 3 g/day for induction, 2 g/day for maintenance; FSGS, IgAN: 1.5-2 g/day; doses adjusted to MPA AUC 30-60 mg·h/L.

How should MMF be adjusted for GI toxicity?

GI side effects (diarrhea, nausea) are dose-dependent; switch to enteric-coated MPA (Myfortic) for comparable immunosuppression with lower upper GI symptoms; split doses, take with food, or reduce total daily dose by 25-50%.

What MPA AUC target is used in transplant TDM?

MPA AUC 30-60 mg·h/L is the standard target post-renal transplant; AUC 60 associated with infections; abbreviated PK protocols (3-4 time points) estimate AUC without full 12h sampling.

Does renal impairment affect MMF dosing?

Severe CKD (GFR <25) increases free MPA fraction; dose reduction or AUC monitoring recommended; MPA metabolite (MPAG) accumulates in ESRD and may competitively displace MPA from albumin binding, increasing free levels.

What teratogenic risks require contraception with MMF?

MMF is highly teratogenic; absolutely contraindicated in pregnancy; women of childbearing potential require two forms of contraception before, during, and 6 weeks after stopping; FDA has required REMS program since 2012.

Mycophenolate Mofetil / Mycophenolic Acid Dosing Calculator

Calculates mycophenolate mofetil (MMF) dosing for transplant immunosuppression, lupus nephritis, and autoimmune indications, with MPA AUC monitoring and dose adjustments for GI intolerance.

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Frequently Asked Questions

What MMF dose is used for renal transplant vs lupus nephritis?

How should MMF be adjusted for GI toxicity?

What MPA AUC target is used in transplant TDM?

Does renal impairment affect MMF dosing?

What teratogenic risks require contraception with MMF?