How does vancomycin dosing differ in neonates versus adults?

Neonates have higher Vd, immature renal elimination, and highly variable PK based on gestational and postnatal age. Standard adult q12h dosing often leads to underdosing; PMA-based extended intervals (q24-48h) with TDM are required.

What are the vancomycin AUC targets in neonates?

Target AUC24 400–600 mg·h/L (assuming MIC 1 mg/L) is used in most neonatal centers, consistent with adult ASHP/IDSA guidelines. Bayesian software using neonatal PK models provides the most accurate dosing recommendations.

Neonatal Vancomycin Extended Interval Dosing

Calculate neonatal vancomycin extended-interval dosing based on gestational age, postnatal age, and weight, using maturation-based pharmacokinetic parameters to achieve therapeutic AUC targets in NICU patients.

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Neonatal Vancomycin Extended Interval Dosing

Frequently Asked Questions

How does vancomycin dosing differ in neonates versus adults?

What are the vancomycin AUC targets in neonates?