What NIHSS score range indicates major stroke?

NIHSS 0 = no stroke; 1-4 = minor stroke; 5-15 = moderate; 15-20 = moderate-severe; >20 = severe stroke. Mechanical thrombectomy benefit is best demonstrated in NIHSS ≥6 with large vessel occlusion on imaging.

Is NIHSS used to determine tPA eligibility?

While no absolute NIHSS cutoff excludes tPA, NIHSS 25 (severe stroke) raises risk-benefit concerns. Current guidelines focus on clinical judgment rather than score thresholds alone.

NIHSS — National Institutes of Health Stroke Scale

Calculate the NIH Stroke Scale (NIHSS) across 11 neurological domains to quantify acute stroke severity, determine thrombolysis eligibility, guide thrombectomy decisions, and predict functional outcomes.

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NIHSS — National Institutes of Health Stroke Scale

Frequently Asked Questions

What NIHSS score range indicates major stroke?

Is NIHSS used to determine tPA eligibility?