PNH Clone Size and Thrombosis Risk Calculator

Calculate PNH clone size from flow cytometry (FLAER/CD59/CD55 on granulocytes and monocytes), estimate thrombosis and haemolysis risk, and determine eculizumab/ravulizumab treatment threshold.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculate PNH clone size from flow cytometry (FLAER/CD59/CD55 on granulocytes and monocytes), estimate thrombosis and haemolysis risk, and determine eculizumab/ravulizumab treatment threshold

Each component has a specific meaning:

  • Flow cytometry (FLAER/CD59/CD55 on granulocytes — The flow cytometry (flaer/cd59/cd55 on granulocytes recorded for the scenario being assessed.
  • Monocytes) — The monocytes) recorded for the scenario being assessed.
  • Estimate thrombosis — The estimate thrombosis recorded for the scenario being assessed.
  • Haemolysis risk — The haemolysis risk recorded for the scenario being assessed.
  • Determine eculizumab/ravulizumab treatment threshold — The determine eculizumab/ravulizumab treatment threshold recorded for the scenario being assessed.

Note: Interpret the pnh clone risk result against the thresholds and context described above.

How to Use

Enter the flow cytometry (FLAER/CD59/CD55 on granulocytes, monocytes), estimate thrombosis, haemolysis risk, determine eculizumab/ravulizumab treatment threshold for the scenario you are assessing. Calculate PNH clone size from flow cytometry (FLAER/CD59/CD55 on granulocytes and monocytes), estimate thrombosis and haemolysis risk, and determine eculizumab/ravulizumab treatment threshold. Use the pnh clone risk result to inform your calculation.

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