What clone size threshold guides eculizumab therapy?

Eculizumab is recommended when granulocyte clone size is >50% with symptomatic haemolysis (transfusion-dependent or elevated LDH >1.5× ULN) or history of thrombosis regardless of clone size.

How is PNH flow cytometry performed?

High-sensitivity flow cytometry using FLAER (fluorescent aerolysin) and CD59/CD55/CD16 on granulocytes (most sensitive) and monocytes. Erythrocyte clone size underestimates due to haemolysis and transfusion.

PNH Clone Size and Thrombosis Risk Calculator

Calculate PNH clone size from flow cytometry (FLAER/CD59/CD55 on granulocytes and monocytes), estimate thrombosis and haemolysis risk, and determine eculizumab/ravulizumab treatment threshold.

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Frequently Asked Questions

What clone size threshold guides eculizumab therapy?

How is PNH flow cytometry performed?