Acute Hepatic Porphyria Attack Severity Calculator

Calculates acute hepatic porphyria (AIP/VP/HCP) attack severity using urinary ALA/PBG, pain score, neurological deficits, hyponatremia, and tachycardia to guide hemin therapy initiation and givosiran dosing.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculates acute hepatic porphyria (AIP/VP/HCP) attack severity using urinary ALA/PBG, pain score, neurological deficits, hyponatremia, and tachycardia to guide hemin therapy initiation and givosiran dosing

Each component has a specific meaning:

  • Urinary ALA/PBG — The urinary ala/pbg recorded for the scenario being assessed.
  • Neurological deficits — The neurological deficits recorded for the scenario being assessed.
  • Hyponatremia — The hyponatremia recorded for the scenario being assessed.
  • Tachycardia — The tachycardia recorded for the scenario being assessed.

Note: Interpret the ahp attack severity result against the thresholds and context described above.

How to Use

Enter the urinary ALA/PBG, neurological deficits, hyponatremia, tachycardia for the scenario you are assessing. Calculates acute hepatic porphyria (AIP/VP/HCP) attack severity using urinary ALA/PBG, pain score, neurological deficits, hyponatremia, and tachycardia to guide hemin therapy initiation and givosiran dosing. Use the ahp attack severity result to inform your calculation.

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