When does amoxicillin require dose reduction in renal failure?

Amoxicillin requires dose adjustment when CrCl <30 mL/min. At CrCl 10-30: standard dose q12h or reduced dose q8h. At CrCl <10 (including HD): 250-500 mg q24h; supplement after each dialysis session.

What is the fraction renally eliminated (fe) for amoxicillin?

Amoxicillin fe ≈ 0.8–0.9 (80-90% renally eliminated). Using DR = 1 - 0.8×(1-KF), a patient with GFR 20% of normal (KF=0.2) should receive approximately 36% of the normal dose rate, e.g., reduced dose or extended interval.

Amoxicillin Renal Dose Adjustment Calculator

Calculate amoxicillin dose adjustment for renal impairment using the fraction eliminated renally (fe) and kidney function ratio (KF) method: DR = 1 - fe×(1-KF), to prevent accumulation in CKD patients.

Use the full interactive calculator below, or

Amoxicillin Renal Dose Adjustment Calculator

Frequently Asked Questions

When does amoxicillin require dose reduction in renal failure?

What is the fraction renally eliminated (fe) for amoxicillin?