Why does risperidone raise prolactin more than other antipsychotics?

Risperidone poorly crosses the blood-brain barrier and has high peripheral D2 blockade in pituitary lactotrophs; less CNS entry means more pituitary D2 blockade.

At what prolactin level are clinical effects expected?

Symptomatic hyperprolactinemia (galactorrhea, amenorrhea, sexual dysfunction) typically occurs at >60-80 mcg/L in women and >50 mcg/L in men.

Risperidone Prolactin Elevation Prediction

Predict prolactin elevation magnitude with risperidone and assess clinical consequences including sexual dysfunction and bone density loss.

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Risperidone Prolactin Elevation Prediction

Frequently Asked Questions

Why does risperidone raise prolactin more than other antipsychotics?

At what prolactin level are clinical effects expected?