What SLEDAI-2K score indicates active lupus requiring treatment escalation?

SLEDAI-2K >4 indicates moderately active disease; >12 indicates highly active lupus warranting aggressive immunosuppression. Scores ≤6 often represent mild activity manageable with hydroxychloroquine and low-dose steroids.

How does SLEDAI-2K differ from the original SLEDAI?

SLEDAI-2K captures persistent activity (ongoing rash, alopecia, mucosal ulcers, proteinuria), whereas the original SLEDAI only scored new or worsening features, making 2K more sensitive for ongoing disease.

SLEDAI-2K — Systemic Lupus Erythematosus Disease Activity

Calculate the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) across 24 clinical and laboratory items to quantify lupus disease activity and guide treatment decisions.

Use the full interactive calculator below, or

SLEDAI-2K — Systemic Lupus Erythematosus Disease Activity

Frequently Asked Questions

What SLEDAI-2K score indicates active lupus requiring treatment escalation?

How does SLEDAI-2K differ from the original SLEDAI?