What is the HFMSE range and clinically meaningful change?

HFMSE ranges 0–66; a ≥3-point increase defines a clinically meaningful improvement, as validated in nusinersen (CHERISH) and risdiplam (SUNFISH) trials.

When is RULM used instead of HFMSE in SMA?

The Revised Upper Limb Module (RULM, 0–37) is used for non-ambulant patients or when tracking arm/hand function specifically. HFMSE and RULM are complementary in most SMA type II/III patients.

HFMSE — Hammersmith Functional Motor Scale for SMA

Assess functional motor abilities in spinal muscular atrophy (SMA) using the Hammersmith Functional Motor Scale Expanded (HFMSE), covering 33 functional activities scored 0–2 each.

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HFMSE — Hammersmith Functional Motor Scale for SMA

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Frequently Asked Questions

What is the HFMSE range and clinically meaningful change?

When is RULM used instead of HFMSE in SMA?