What anti-GAD65 titer level confirms stiff person syndrome?

Anti-GAD65 titers >1000 IU/mL (>10× ULN) are highly specific for autoimmune neurological disease including SPS. Lower titers are more common in type 1 diabetes without neurological involvement.

What treatments are used for stiff person syndrome?

First-line: diazepam (20–80 mg/day) and baclofen (60–120 mg/day) for symptomatic relief. Immunotherapy: IVIG (2 g/kg every 4–6 weeks) for moderate-severe SPS; rituximab for refractory cases.

Stiff Person Syndrome Disability and Anti-GAD Titer

Assess functional disability in stiff person syndrome (SPS) and correlate anti-GAD65 antibody titers with disease severity, fall risk, and response to IVIG, diazepam, baclofen, and rituximab therapy.

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Stiff Person Syndrome Disability and Anti-GAD Titer

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Frequently Asked Questions

What anti-GAD65 titer level confirms stiff person syndrome?

What treatments are used for stiff person syndrome?