Transthyretin Amyloidosis (ATTR) Progression Calculator

Calculates ATTR amyloidosis progression using the Neuropathy Impairment Score (NIS), FAS composite, polyneuropathy disability score, and cardiac biomarkers (NT-proBNP, troponin) to guide patisiran/inotersen dosing.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Calculates ATTR amyloidosis progression using the Neuropathy Impairment Score (NIS), FAS composite, polyneuropathy disability score, and cardiac biomarkers (NT-proBNP, troponin) to guide patisiran/inotersen dosing

Each component has a specific meaning:

  • FAS composite — The fas composite recorded for the scenario being assessed.
  • Cardiac biomarkers (NT-proBNP — The cardiac biomarkers (nt-probnp recorded for the scenario being assessed.
  • Troponin) — The troponin) recorded for the scenario being assessed.

Note: Interpret the attr progression result against the thresholds and context described above.

How to Use

Enter the FAS composite, cardiac biomarkers (NT-proBNP, troponin) for the scenario you are assessing. Calculates ATTR amyloidosis progression using the Neuropathy Impairment Score (NIS), FAS composite, polyneuropathy disability score, and cardiac biomarkers (NT-proBNP, troponin) to guide patisiran/inotersen dosing. Use the attr progression result to inform your calculation.

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Frequently Asked Questions