How do the partial and full Mayo scores relate?

The partial Mayo drops the endoscopic subscore and the physician global assessment, leaving stool frequency, rectal bleeding, and a clinician rating for a 0 to 9 range. It is used between endoscopies to track response, while the full 0 to 12 score is reserved for visits where flexible sigmoidoscopy is performed.

What counts as endoscopic remission on the Mayo subscore?

A subscore of 0 (normal or inactive mucosa) or 1 (mild friability and loss of vascular pattern) is generally accepted as endoscopic remission. A subscore of 2 or 3 indicates active disease and is the usual threshold for escalating therapy in treat-to-target protocols.

Is the Mayo score still the standard endpoint in trials?

It remains the most widely used composite, but regulators increasingly ask for combined clinical and endoscopic endpoints, and the more granular endoscopic subscore from the Ulcerative Colitis Endoscopic Index of Severity is sometimes preferred for central reading.

Ulcerative Colitis Mayo Score and Partial Mayo Index

Compute the four-part Mayo score for ulcerative colitis and its three-part partial version. Remission is 0 to 2, mild 3 to 5, moderate 6 to 10, and severe 11 to 12, with the endoscopic subscore reported separately.

Four items scored 0–3 (total 0–12). The partial Mayo omits endoscopy and sums the first three items (0–9).

1.Stool frequency

2.Rectal bleeding

3.Physician's global assessment

4.Endoscopic findings (mucosal appearance)

0/ 12

Mayo score 0 — Remission

Total score	Activity
0–2	Remission
3–5	Mild activity
6–10	Moderate activity
11–12	Severe activity

Clinical Guidance

The Mayo score (also called the Disease Activity Index) combines four items — stool frequency, rectal bleeding, physician's global assessment, and endoscopic findings — each scored 0–3, for a total of 0–12. Scores of 0–2 indicate remission, 3–5 mild, 6–10 moderate, and 11–12 severe disease. A reduction of 3 points or more, or a score of 0 or 1, is commonly used to define clinical response or remission in trials.

The partial Mayo omits the endoscopic sub-score and uses only the three clinical items (0–9), which makes it suitable for frequent non-invasive monitoring between endoscopies. Because the full and partial scores use different denominators, compare like with like when tracking a patient over time.

How to Use

Enter the values for the scenario you are assessing. Compute the four-part Mayo score for ulcerative colitis and its three-part partial version. Remission is 0 to 2, mild 3 to 5, moderate 6 to 10, and severe 11 to 12, with the endoscopic subscore reported separately. Use the mayo score (uc) result to inform your calculation.

Formula Sources

Related Calculators

Mayo Score UC

Medical

CDAI