What UAS7 range defines disease severity in chronic urticaria?

UAS7 range 0-42 (0-6 daily, 7 days); 0-6: well-controlled; 7-15: mild activity; 16-27: moderate; 28-42: severe; UAS7 ≤7 is the treatment target; ≤16 represents moderate response to treatment.

What is the first-line treatment for chronic spontaneous urticaria?

2nd generation non-sedating antihistamines at standard dose (cetirizine 10 mg, fexofenadine 180 mg, loratadine 10 mg) once daily; if inadequate after 2-4 weeks, updose to 4x standard dose; licensed updosing before adding omalizumab.

When is omalizumab indicated for chronic urticaria?

Omalizumab 300 mg SC q4 weeks is indicated for H1 antihistamine-refractory CSU (UAS7 >16 despite antihistamines); ASTERIA II trial: 52% complete response (UAS7=0) vs 5% placebo; treatment typically 6-12 months minimum.

What is the difference between chronic spontaneous and chronic inducible urticaria?

CSU: wheals without identifiable physical trigger (autoimmune or idiopathic); CIndU: specific physical triggers (cold urticaria, symptomatic dermographism, delayed pressure urticaria, solar urticaria); treatment differs; UAS7 designed for CSU.

What laboratory tests are useful in CSU evaluation?

FBC, ESR/CRP (exclude inflammatory/autoimmune cause), thyroid antibodies (TPO abs in 25% of CSU), autologous serum skin test or basophil histamine release for autoimmune subtype; ANA, complement for suspect urticarial vasculitis.

Urticaria Activity Score (UAS7) and H1 Antihistamine Response Monitoring

Calculates the 7-day Urticaria Activity Score (UAS7) from daily wheal and itch scores to assess chronic spontaneous urticaria severity and monitor response to antihistamine and omalizumab treatment.

Weight

Height

Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Calculates the 7-day Urticaria Activity Score (UAS7) from daily wheal and itch scores to assess chronic spontaneous urticaria severity and monitor response to antihistamine and omalizumab treatment

Each component has a specific meaning:

Daily wheal — The daily wheal recorded for the patient or scenario being assessed.

Note: Interpret the uas7 urticaria result against the clinical thresholds and context described above.

How to Use

Enter the daily wheal for the patient or scenario you are assessing. Calculates the 7-day Urticaria Activity Score (UAS7) from daily wheal and itch scores to assess chronic spontaneous urticaria severity and monitor response to antihistamine and omalizumab treatment. Use the uas7 urticaria result to inform your clinical assessment.

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