What ISTH-BAT score is diagnostic for VWD?

ISTH-BAT score ≥3 in females and ≥2 in males raises suspicion for VWD; score ≥3 has ~90% specificity; used alongside VWF:Ag, VWF:RCo (GPIbM), and FVIII:C for diagnosis.

What is the ISTH-BAT bleeding score categories?

Epistaxis, cutaneous bleeding, minor wounds, oral cavity, GI bleeding, menorrhagia, postpartum bleeding, muscle hematomas, hemarthroses, CNS bleeding are scored 0-4 each; a higher score means more severe bleeding history.

Which VWD type responds to DDAVP?

Type 1 VWD (quantitative deficiency with normal qualitative VWF) typically responds well to DDAVP (desmopressin) 0.3 mcg/kg IV/SC; Type 2A/2B/2N may respond variably; Type 3 does not respond (no VWF stores).

What VWF levels confirm VWD diagnosis?

VWF:Ag <50 IU/dL (normal 50-200) combined with VWF activity <50 IU/dL and/or FVIII:C <50 IU/dL confirms VWD; borderline 50-80 IU/dL with bleeding symptoms is classified as low VWF.

What is the menorrhagia treatment for VWD females?

Combined OCP or LNG-IUS first-line for menorrhagia; tranexamic acid for all bleeding episodes; DDAVP or VWF concentrate for surgery/dental procedures depending on VWD type and severity.

Von Willebrand Disease Bleeding Assessment Tool (ISTH-BAT)

Calculates the ISTH Bleeding Assessment Tool score to identify patients with significant mucocutaneous bleeding for von Willebrand disease screening, with DDAVP response prediction by VWD type.

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Von Willebrand Disease Bleeding Assessment Tool (ISTH-BAT)

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Frequently Asked Questions

What ISTH-BAT score is diagnostic for VWD?

What is the ISTH-BAT bleeding score categories?

Which VWD type responds to DDAVP?

What VWF levels confirm VWD diagnosis?

What is the menorrhagia treatment for VWD females?