Two-Compartment PK Model Alpha-Beta Phase

Fit biexponential plasma concentration-time curve and extract alpha (distribution) and beta (elimination) phase rate constants.

 
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Physical Constants Reference
ConstantSymbolValue
Speed of lightc2.99792458×10⁸
Planck's constanth6.62607015×10⁻³‴
Boltzmann constant1.380649×10⁻²³
Avogadro's numberNₐ6.02214076×10²³
Gravitational constantG6.6743×10⁻¹¹
Gas constantR8.31446
Elementary chargee1.602176634×10⁻¹⁹
Electron massmₑ9.1093837015×10⁻³¹
Proton massmₚ1.67262192369×10⁻²⁷
Fine-structure constantα7.2973525693×10⁻³
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How to Use

Enter the values for the patient or scenario you are assessing. Fit biexponential plasma concentration-time curve and extract alpha (distribution) and beta (elimination) phase rate constants. Use the two-compartment pk result to inform your clinical assessment.

Frequently Asked Questions