Acetaminophen Toxicity Rumack-Matthew Nomogram

Applies the Rumack-Matthew nomogram to determine N-acetylcysteine (NAC) treatment necessity based on serum acetaminophen level and hours post-ingestion, with NAC dosing protocol for IV and oral routes.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Applies the Rumack-Matthew nomogram to determine N-acetylcysteine (NAC) treatment necessity based on serum acetaminophen level and hours post-ingestion, with NAC dosing protocol for IV and oral routes

Each component has a specific meaning:

  • Serum acetaminophen level — The serum acetaminophen level recorded for the scenario being assessed.
  • Hours post-ingestion — The hours post-ingestion recorded for the scenario being assessed.

Note: Interpret the acetaminophen nomogram result against the thresholds and context described above.

How to Use

Enter the serum acetaminophen level, hours post-ingestion for the scenario you are assessing. Applies the Rumack-Matthew nomogram to determine N-acetylcysteine (NAC) treatment necessity based on serum acetaminophen level and hours post-ingestion, with NAC dosing protocol for IV and oral routes. Use the acetaminophen nomogram result to inform your calculation.

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Frequently Asked Questions