Azathioprine TPMT/NUDT15 Pharmacogenomics Dose Calculator

Calculates azathioprine/mercaptopurine dose based on TPMT and NUDT15 genotype per CPIC guidelines, starting dose for IBD (2-2.5 mg/kg/day) and autoimmune disease, and thiopurine metabolite monitoring.

Weight
Height
Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
Advertisement

How It Works

Calculates azathioprine/mercaptopurine dose based on TPMT and NUDT15 genotype per CPIC guidelines, starting dose for IBD (2-2.5 mg/kg/day) and autoimmune disease, and thiopurine metabolite monitoring

Each component has a specific meaning:

  • TPMT — The tpmt recorded for the scenario being assessed.
  • NUDT15 genotype per CPIC guidelines — The nudt15 genotype per cpic guidelines recorded for the scenario being assessed.
  • Starting dose — The starting dose recorded for the scenario being assessed.

Note: Interpret the aza tpmt dosing result against the thresholds and context described above.

How to Use

Enter the TPMT, NUDT15 genotype per CPIC guidelines, starting dose for the scenario you are assessing. Calculates azathioprine/mercaptopurine dose based on TPMT and NUDT15 genotype per CPIC guidelines, starting dose for IBD (2-2.5 mg/kg/day) and autoimmune disease, and thiopurine metabolite monitoring. Use the aza tpmt dosing result to inform your calculation.

Related Calculators

Warfarin Dosing

Medical Calculators

Tacrolimus PGx

Medical Calculators

MMF Dosing

Medical Calculators

Frequently Asked Questions