What serum calprotectin level indicates RA flare?

Serum calprotectin (S100A8/A9 complex) >3,000 ng/mL is associated with high DAS28 activity. It reflects synovial macrophage activation and may predict flare before CRP rises, especially useful in tocilizumab-treated patients where CRP is suppressed.

How does fecal calprotectin relate to IBD?

Fecal calprotectin >250 µg/g indicates active IBD inflammation; >500 µg/g is highly specific for active disease. It differentiates IBD from IBS and correlates with endoscopic findings.

Can calprotectin monitor biologic therapy response?

Yes. Serial calprotectin decreases correlate with DAPSA and DAS28 improvement. Persistently elevated calprotectin despite clinical improvement may indicate subclinical synovitis detected by ultrasound.

Calprotectin as Rheumatoid Arthritis Flare Marker

Interpret serum and fecal calprotectin levels as biomarkers of inflammation in rheumatoid arthritis and IBD overlap. Serum calprotectin (S100A8/A9) reflects joint macrophage activation; fecal calprotectin indicates gut inflammation.

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