What are the five factors in the FFS?

Proteinuria >1g/day (+1), creatinine >1.58mg/dL (+1), cardiomyopathy (+1), GI involvement (+1), and age >65 (+1). Each factor adds 1 point. Original 1996 FFS included ear, nose, throat involvement as a protective factor (−1 for EGPA).

What FFS score justifies cyclophosphamide?

FFS ≥1 predicts 5-year mortality >25% and justifies adding cyclophosphamide to corticosteroids. FFS 0 (low-risk) may be managed with steroids alone in PAN and EGPA.

Has the FFS been revised?

Yes. The 2011 revised FFS removed ear/nose/throat as protective factor for EGPA and updated cutoffs. Age >65 was added as a factor, and GI tract involvement was redefined.

Five Factor Score (FFS) for Systemic Necrotizing Vasculitis

Calculate the Five Factor Score (FFS) for polyarteritis nodosa, eosinophilic GPA, and MPA. Predicts 5-year mortality and guides cyclophosphamide use: FFS ≥1 justifies immunosuppressive therapy.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How to Use

Enter the values for the scenario you are assessing. Calculate the Five Factor Score (FFS) for polyarteritis nodosa, eosinophilic GPA, and MPA. Predicts 5-year mortality and guides cyclophosphamide use: FFS ≥1 justifies immunosuppressive therapy. Use the five factor score vasculitis result to inform your calculation.

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