What are the IGA score definitions?

IGA 0 = clear (no inflammatory signs); IGA 1 = almost clear (barely perceptible erythema); IGA 2 = mild (slight but definite erythema, minimal papulation); IGA 3 = moderate (clearly perceptible erythema, moderate papulation); IGA 4 = severe (marked erythema, severe papulation/oozing).

What is the IGA 0/1 endpoint?

IGA 0 or 1 with ≥2-point improvement from baseline is the standard regulatory endpoint for atopic dermatitis treatments. This 'clear or almost clear' definition is required by FDA and EMA for approval.

IGA Investigator's Global Assessment for Eczema

Assess overall atopic dermatitis severity using the Investigator's Global Assessment (IGA) 5-point scale from 0 (clear) to 4 (severe), used as a regulatory endpoint for biologic and JAK inhibitor trials.

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Frequently Asked Questions

What are the IGA score definitions?

What is the IGA 0/1 endpoint?