Sharp Criteria for Mixed Connective Tissue Disease (MCTD)

Apply Sharp diagnostic criteria for mixed connective tissue disease (MCTD). Characterized by features of SLE, SSc, polymyositis, and RA with high-titer anti-U1-RNP antibodies. Distinguishes MCTD from overlap syndromes.

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Clinical Guidance

BMI is a screening measure of body size, not a direct measure of body fat. The standard WHO categories are underweight (<18.5), normal (18.5–24.9), overweight (25–29.9), and obese (≥30).

BMI can overestimate body fat in athletes with high muscle mass and underestimate it in older adults with low muscle mass. Interpret it alongside waist circumference and clinical context rather than as a standalone diagnosis.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.
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How It Works

Apply Sharp diagnostic criteria for mixed connective tissue disease (MCTD). Characterized by features of SLE, SSc, polymyositis, and RA with high-titer anti-U1-RNP antibodies. Distinguishes MCTD from overlap syndromes

Each component has a specific meaning:

  • Overlap syndromes — The overlap syndromes recorded for the scenario being assessed.

Note: Interpret the mctd sharp criteria result against the thresholds and context described above.

How to Use

Enter the overlap syndromes for the scenario you are assessing. Apply Sharp diagnostic criteria for mixed connective tissue disease (MCTD). Characterized by features of SLE, SSc, polymyositis, and RA with high-titer anti-U1-RNP antibodies. Distinguishes MCTD from overlap syndromes. Use the mctd sharp criteria result to inform your calculation.

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Frequently Asked Questions