What are the Yamaguchi major criteria for adult Still's disease?

Major criteria: quotidian fever ≥39°C, arthralgia/arthritis, typical salmon-pink rash, leukocytosis (WBC ≥10,000 with ≥80% PMNs). Minor criteria: sore throat, lymphadenopathy/splenomegaly, liver dysfunction, negative ANA and RF. Sensitivity 96.2%, specificity 92.1%.

What ferritin level supports adult Still's disease diagnosis?

Ferritin >5× ULN (typically >1000 ng/mL) is common; ferritin >10,000 ng/mL with glycosylated fraction <20% is highly specific for AOSD and MAS. Ferritin tracks disease activity and responds to IL-1 or IL-6 inhibitor therapy.

Adult Still's Disease Yamaguchi Criteria Score

Apply Yamaguchi criteria to diagnose adult-onset Still's disease: requires 5+ criteria (≥2 major) after excluding infections, malignancies, and rheumatic diseases.

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Adult Still's Disease Yamaguchi Criteria Score

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Frequently Asked Questions

What are the Yamaguchi major criteria for adult Still's disease?

What ferritin level supports adult Still's disease diagnosis?