What changed in AJCC 8th edition for melanoma?

AJCC 8th changes: T1b now uses 0.8mm cutoff + ulceration (removed mitosis). N categories separated satellite lesions, microsatellites. M1d added (CNS metastasis). 10-year survival data included. Removed Clark level from T staging.

What is Stage III melanoma?

Stage III: any T with regional nodal (N) involvement (micrometastasis detected by SLNB, macroscopic clinically detectable nodes, satellite/in-transit lesions with or without nodal involvement). 5-year survival 40-78% depending on substage.

When is adjuvant immunotherapy indicated after melanoma resection?

Adjuvant pembrolizumab or nivolumab is recommended for Stage III-IV (fully resected) melanoma. Adjuvant dabrafenib+trametinib for BRAF V600-mutant Stage III. 1-year treatment reduces relapse risk ~40-50% vs placebo.

AJCC 8th Melanoma Staging TNM

Apply AJCC 8th edition melanoma TNM staging from T (Breslow + ulceration), N (nodal number + microsatellitosis), and M (distant metastasis LDH) categories.

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Breslow Depth Melanoma

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AJCC 8th Melanoma Staging TNM

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Frequently Asked Questions

What changed in AJCC 8th edition for melanoma?

What is Stage III melanoma?

When is adjuvant immunotherapy indicated after melanoma resection?