What is the once-daily aminoglycoside dose?

Gentamicin and tobramycin: 5-7 mg/kg ideal body weight q24h. Amikacin: 15-20 mg/kg q24h. Once-daily dosing exploits concentration-dependent killing and post-antibiotic effect while reducing nephrotoxicity.

How is the Hartford nomogram used?

Obtain a drug level 6-14 hours post-dose. Plot on the Hartford nomogram to determine if dosing interval should be q24h, q36h, or q48h based on renal function and desired PK targets.

Which patients should NOT receive once-daily aminoglycosides?

Avoid in: endocarditis (requires synergistic twice-daily dosing), pregnancy, CrCl 20% BSA, significant ascites, and paediatric patients where PK may differ.

Aminoglycoside Once-Daily Dosing Calculator

Calculate once-daily aminoglycoside dosing (gentamicin 5-7 mg/kg, tobramycin 5-7 mg/kg q24h). Hartford nomogram for monitoring and dose adjustment.

Use the full interactive calculator below, or

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