Why is AUC/MIC preferred over trough-only monitoring?

AUC/MIC 400-600 h*mg/L provides better efficacy prediction and lower nephrotoxicity risk compared to trough-only monitoring. Troughs > 15-20 mg/L were associated with increased nephrotoxicity without improved outcomes.

How is vancomycin AUC estimated at steady state?

Bayesian-assisted AUC estimation using two-level PK sampling (peak ~1-2 h post-infusion, trough pre-dose) is the preferred method. Two-point sampling with PK software is more accurate than single trough.

What is the typical vancomycin dose?

Initial loading dose 25-30 mg/kg IV for severe infections. Maintenance 15-20 mg/kg q8-12h, adjusted for renal function. Infuse over 60 minutes or more (or 1 hour per 500 mg) to prevent red man syndrome.

Vancomycin AUC-Guided Dosing Calculator

Calculate vancomycin AUC/MIC ratio for optimised dosing. Target AUC/MIC 400-600 mg*h/L per 2020 ASHP/IDSA/SIDP guidelines to maximise efficacy and minimise nephrotoxicity.

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Frequently Asked Questions

Why is AUC/MIC preferred over trough-only monitoring?

How is vancomycin AUC estimated at steady state?

What is the typical vancomycin dose?