What is the bivalirudin dosing protocol for PCI?

Bivalirudin PCI: 0.75 mg/kg IV bolus + 1.75 mg/kg/h infusion during procedure. Target ACT 300–350 seconds (measured 5 min post-bolus). Continue 0.2 mg/kg/h for up to 4 hours post-PCI if needed. Dose adjustments: CrCl <30 mL/min: reduce infusion to 1.0 mg/kg/h.

How is bivalirudin used for HIT with thrombosis?

For HIT+: bivalirudin 0.15–0.2 mg/kg/h continuous infusion (lower than PCI dose). Target aPTT 1.5–2.5× baseline. Hepatic dosage reduction: reduce 20% for moderate, 50% for severe hepatic impairment. Argatroban preferred in renal failure; bivalirudin preferred in severe hepatic failure.

Bivalirudin Infusion Rate by ACT Calculator

Calculate bivalirudin infusion rate adjustments for PCI and HIT anticoagulation based on activated clotting time (ACT) targets: 300–350 seconds during PCI, or aPTT 1.5–2.5× normal for HIT.

⚕ Clinical Disclaimer: These calculators are for educational and reference purposes only. Always verify results with qualified clinical judgment and current clinical guidelines. Do not use as a sole basis for medical decisions.

How It Works

Calculate bivalirudin infusion rate adjustments for PCI and HIT anticoagulation based on activated clotting time (ACT) targets: 300–350 seconds during PCI, or aPTT 1.5–2.5× normal for HIT

Each component has a specific meaning:

Activated clotting time targets: 300–350 seconds during PCI — The activated clotting time targets: 300–350 seconds during pci recorded for the scenario being assessed.
Or aPTT 1 — The or aptt 1 recorded for the scenario being assessed.

Note: Interpret the bivalirudin act rate result against the thresholds and context described above.

How to Use

Enter the activated clotting time targets: 300–350 seconds during PCI, or aPTT 1 for the scenario you are assessing. Calculate bivalirudin infusion rate adjustments for PCI and HIT anticoagulation based on activated clotting time (ACT) targets: 300–350 seconds during PCI, or aPTT 1.5–2.5× normal for HIT. Use the bivalirudin act rate result to inform your calculation.

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