What is the starting dose of cinacalcet?

Cinacalcet starts at 30 mg once daily with food. Titrate by 30 mg increments every 2-4 weeks. Maximum dose is 180 mg/day. Doses of 60, 90, 120, and 180 mg are available.

What is the PTH target for dialysis patients on cinacalcet?

KDIGO 2017 suggests maintaining intact PTH 2-9x the upper limit of normal (approximately 150-600 pg/mL). The goal is to avoid both over- and undersuppression of PTH.

What are key side effects of cinacalcet?

Hypocalcaemia (most common, monitor serum calcium), nausea and vomiting (take with food), QT prolongation. Do not use if corrected serum calcium < 8.4 mg/dL.

Cinacalcet Dosing for Secondary Hyperparathyroidism

Calculate cinacalcet dosing for secondary hyperparathyroidism (sHPT) in dialysis patients. Starting dose 30 mg daily; titrate every 2-4 weeks to PTH target 150-300 pg/mL.

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