What eosinophil count defines hypereosinophilia?

Hypereosinophilia (HE): absolute eosinophil count (AEC) >=1500/uL on two occasions >=1 month apart or single reading with tissue eosinophilia/organ damage. Hypereosinophilic syndrome (HES): HE plus organ damage including cardiac.

What cardiac complications occur in eosinophilic disease?

Loeffler endocarditis: necrotic phase (eosinophilic myocarditis), thrombotic phase (mural thrombus), fibrotic phase (restrictive cardiomyopathy). Cardiac troponin elevation and MRI are key diagnostic tools.

How is eosinophilic myocarditis treated?

Treat underlying cause (drug reaction, parasitic infection, malignancy). Corticosteroids for idiopathic/HES-related myocarditis. Imatinib for FIP1L1-PDGFRA fusion HES. Anticoagulation for thrombotic phase.

Eosinophilic Myocarditis Hypereosinophilia Threshold

Diagnose and risk-stratify eosinophilic myocarditis using peripheral blood eosinophil count. Hypereosinophilia (>1500/uL x6 weeks or >1500/uL with organ damage) is diagnostic threshold.

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