Identifies discordance between LDL particle number (LDL-P) and LDL cholesterol (LDL-C). LDL-P >1000 nmol/L indicates high cardiovascular risk regardless of LDL-C level. Discordance is especially prevalent in insulin resistance, metabolic syndrome, and hypertriglyceridemia where LDL-C may underestimate atherogenic particle burden.
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