Evaluates Lp(a) level as an independent cardiovascular risk factor. Lp(a) >50 mg/dL (or >125 nmol/L) constitutes an independent CV risk factor. Lp(a) is genetically determined (~90% heritability), not substantially reduced by statins, and elevated in 20–25% of the global population. Informs eligibility for PCSK9 inhibitors and emerging Lp(a)-lowering therapies.
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