What lithium levels indicate mild, moderate, and severe toxicity?

Toxicity risk correlates with level and acuity: acute toxicity (overdose) often tolerated at higher levels than chronic. Chronic toxicity: 1.5–2.0 mmol/L mild (tremor, polyuria), 2.0–2.5 mmol/L moderate (drowsiness, ataxia, confusion), >2.5 mmol/L severe (seizures, renal failure, cardiac). Therapeutic: 0.6–1.2 mmol/L.

What drugs increase lithium toxicity risk?

NSAIDs (reduce renal clearance by 25–60%), ACE inhibitors/ARBs (reduce clearance 20–40%), thiazide diuretics, dehydration/low sodium diet (enhance proximal tubular reabsorption), metronidazole, tetracyclines. Hemodialysis is required for severe toxicity with level >4.0 mmol/L or severe symptoms.

Lithium Level Toxicity Risk Calculator

Assess lithium toxicity risk based on serum level (12h post-dose), renal function, dehydration, NSAID/ACE inhibitor co-prescription, and clinical symptoms of intoxication.

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Frequently Asked Questions

What lithium levels indicate mild, moderate, and severe toxicity?

What drugs increase lithium toxicity risk?