What is the Cockcroft-Gault formula?

CrCl = (140 - age) × weight / (72 × Cr) × 0.85 (if female). Weight is actual for normal/underweight patients, IBW for obese patients.

How does CrCl differ from eGFR?

CrCl from Cockcroft-Gault estimates tubular secretion + filtration. CKD-EPI eGFR estimates filtration only. CrCl is used for drug dosing; eGFR for CKD staging.

What CrCl requires dose adjustment?

Most renally-cleared drugs require adjustment at CrCl <50 mL/min, with significant adjustments at <30 mL/min, and contraindication at <10-15 mL/min.

Creatinine Clearance (Cockcroft-Gault)

Calculate creatinine clearance using the Cockcroft-Gault formula — standard for renal drug dosing adjustments.

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Frequently Asked Questions

What is the Cockcroft-Gault formula?

How does CrCl differ from eGFR?

What CrCl requires dose adjustment?