How does arrhythmic trigger differ by LQTS genotype?

LQT1 events are triggered by exercise (especially swimming); LQT2 by startle/auditory stimuli; LQT3 at rest or sleep. Beta-blocker effectiveness is highest in LQT1, moderate in LQT2.

What QTc is high risk in LQTS?

QTc >500ms is associated with significantly higher arrhythmic risk across all genotypes. In LQT2, QTc >500ms or female sex with QTc >480ms indicates very high risk.

When is ICD indicated in LQTS?

ICD is indicated after cardiac arrest or sustained VT. ICD is reasonable for high-risk LQTS patients with QTc >500ms, recurrent syncope on beta-blockers, or LQT3 with cardiac events.

LQTS QTc by Genotype Risk

Assess QTc-based arrhythmic risk stratification in long QT syndrome by genotype: LQT1 (KCNQ1), LQT2 (KCNH2), LQT3 (SCN5A) have distinct triggers and risk thresholds.

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LQTS QTc by Genotype Risk

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Frequently Asked Questions

How does arrhythmic trigger differ by LQTS genotype?

What QTc is high risk in LQTS?

When is ICD indicated in LQTS?